Abstract
Antibiotic-impregnated polymethylmethacrylate (PMMA) beads have improved the outcome of osteomyelitis treatment in both experimental models and clinical trials. The primary benefit of antibiotic-impregnated PMMA beads is that they provide high local concentrations of antibiotic while systemic levels of antibiotic remain low. Little has been written about the specific use of antibiotic-impregnated PMMA beads in the treatment of diabetic pedal osteomyelitis. The authors review antibiotic-impregnated PMMA beads and provide examples of their use in the treatment of diabetic pedal osteomyelitis.
MeSH terms
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Absorbable Implants
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Aged
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Anti-Bacterial Agents / administration & dosage*
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Anti-Bacterial Agents / adverse effects
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Anti-Bacterial Agents / pharmacology
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Biocompatible Materials / chemistry
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Bone Cements / chemistry
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Debridement
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Diabetes Complications*
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Diabetes Mellitus, Type 1 / complications
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Drug Carriers
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Drug Delivery Systems
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Foot Diseases / drug therapy*
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Foot Diseases / surgery
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Humans
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Male
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Middle Aged
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Osteomyelitis / drug therapy*
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Osteomyelitis / surgery
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Polymethyl Methacrylate / chemistry
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Staphylococcal Infections / drug therapy
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Tobramycin / administration & dosage
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Treatment Outcome
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Vancomycin / administration & dosage
Substances
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Anti-Bacterial Agents
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Biocompatible Materials
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Bone Cements
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Drug Carriers
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Vancomycin
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Polymethyl Methacrylate
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Tobramycin