Antibiotic beads in the treatment of diabetic pedal osteomyelitis

J Foot Ankle Surg. 2000 Mar-Apr;39(2):124-30. doi: 10.1016/s1067-2516(00)80037-x.

Abstract

Antibiotic-impregnated polymethylmethacrylate (PMMA) beads have improved the outcome of osteomyelitis treatment in both experimental models and clinical trials. The primary benefit of antibiotic-impregnated PMMA beads is that they provide high local concentrations of antibiotic while systemic levels of antibiotic remain low. Little has been written about the specific use of antibiotic-impregnated PMMA beads in the treatment of diabetic pedal osteomyelitis. The authors review antibiotic-impregnated PMMA beads and provide examples of their use in the treatment of diabetic pedal osteomyelitis.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Absorbable Implants
  • Aged
  • Anti-Bacterial Agents / administration & dosage*
  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / pharmacology
  • Biocompatible Materials / chemistry
  • Bone Cements / chemistry
  • Debridement
  • Diabetes Complications*
  • Diabetes Mellitus, Type 1 / complications
  • Drug Carriers
  • Drug Delivery Systems
  • Foot Diseases / drug therapy*
  • Foot Diseases / surgery
  • Humans
  • Male
  • Middle Aged
  • Osteomyelitis / drug therapy*
  • Osteomyelitis / surgery
  • Polymethyl Methacrylate / chemistry
  • Staphylococcal Infections / drug therapy
  • Tobramycin / administration & dosage
  • Treatment Outcome
  • Vancomycin / administration & dosage

Substances

  • Anti-Bacterial Agents
  • Biocompatible Materials
  • Bone Cements
  • Drug Carriers
  • Vancomycin
  • Polymethyl Methacrylate
  • Tobramycin