Cefodizime enhances phagocytosis and intracellular killing of Staphylococcus aureus but does not influence polymorphonuclear leukocytes response to fMLP stimulation

Int J Immunopharmacol. 2000 Jul;22(7):557-66. doi: 10.1016/s0192-0561(00)00019-9.

Abstract

The influence of Cefodizime (CDZ) on in vitro activity of polymorphonuclear leukocytes (PMNL) from healthy subjects was assessed. Preincubation with CDZ enhanced phagocytosis and intracellular killing of Staphylococcus aureus by PMNL. Contrary to numerous clinical reports, no significant effect of CDZ preincubation on PMNL response to n-formyl-methionyl-leucyl-phenylalanine was found with respect to intracellular calcium changes, degranulation, hydrogen peroxide production, and chemiluminescence. These results suggest that augmented microbicidal activity of PMNL is not related to the enhanced production of reactive oxygen species in healthy subjects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Immunologic / pharmacology*
  • Adult
  • Anti-Bacterial Agents / pharmacology*
  • Calcium / metabolism
  • Cefotaxime / analogs & derivatives*
  • Cefotaxime / pharmacology
  • Cell Degranulation / drug effects
  • Cell Degranulation / immunology
  • Female
  • Humans
  • Hydrogen Peroxide / metabolism
  • Intracellular Fluid / drug effects
  • Intracellular Fluid / immunology
  • Intracellular Fluid / metabolism
  • Luminescent Measurements
  • Male
  • N-Formylmethionine Leucyl-Phenylalanine / immunology*
  • Neutrophils / drug effects*
  • Neutrophils / immunology*
  • Phagocytosis / drug effects*
  • Phagocytosis / immunology
  • Staphylococcus aureus / genetics
  • Staphylococcus aureus / immunology*

Substances

  • Adjuvants, Immunologic
  • Anti-Bacterial Agents
  • N-Formylmethionine Leucyl-Phenylalanine
  • Hydrogen Peroxide
  • Cefotaxime
  • Calcium
  • cefodizime