Abstract
Five new triterpene glucosides, quadranosides I-V (1-5), have been isolated from a MeOH extract of the seeds of Combretum quadrangulare, together with 13 known compounds. The structures of compounds 1-5 were elucidated on the basis of spectroscopic analysis. Among the new triterpene glucosides, three compounds (1, 2, 5) showed significant hepatoprotective effects against D-galactosamine (D-GalN)/tumor necrosis factor-alpha (TNF-alpha)-induced cell death in primary cultured mouse hepatocytes.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Africa
-
Animals
-
Antineoplastic Agents, Phytogenic / isolation & purification*
-
Antineoplastic Agents, Phytogenic / pharmacology
-
Asia
-
Cells, Cultured
-
Chemical and Drug Induced Liver Injury / prevention & control
-
Chromatography, Thin Layer
-
Liver / cytology
-
Liver / drug effects
-
Liver / metabolism
-
Magnetic Resonance Spectroscopy
-
Mass Spectrometry
-
Mice
-
Plants, Medicinal / chemistry*
-
Saponins / isolation & purification*
-
Saponins / pharmacology
-
Seeds / chemistry
-
Spectrophotometry, Ultraviolet
-
Tumor Necrosis Factor-alpha / biosynthesis
Substances
-
Antineoplastic Agents, Phytogenic
-
Saponins
-
Tumor Necrosis Factor-alpha