Quadranosides I-V, new triterpene glucosides from the seeds of Combretum quadrangulare

J Nat Prod. 2000 Apr;63(4):496-500. doi: 10.1021/np990581+.

Abstract

Five new triterpene glucosides, quadranosides I-V (1-5), have been isolated from a MeOH extract of the seeds of Combretum quadrangulare, together with 13 known compounds. The structures of compounds 1-5 were elucidated on the basis of spectroscopic analysis. Among the new triterpene glucosides, three compounds (1, 2, 5) showed significant hepatoprotective effects against D-galactosamine (D-GalN)/tumor necrosis factor-alpha (TNF-alpha)-induced cell death in primary cultured mouse hepatocytes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Africa
  • Animals
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Asia
  • Cells, Cultured
  • Chemical and Drug Induced Liver Injury / prevention & control
  • Chromatography, Thin Layer
  • Liver / cytology
  • Liver / drug effects
  • Liver / metabolism
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Mice
  • Plants, Medicinal / chemistry*
  • Saponins / isolation & purification*
  • Saponins / pharmacology
  • Seeds / chemistry
  • Spectrophotometry, Ultraviolet
  • Tumor Necrosis Factor-alpha / biosynthesis

Substances

  • Antineoplastic Agents, Phytogenic
  • Saponins
  • Tumor Necrosis Factor-alpha