Synthesis and antifungal activity of a ferrocene-fluconazole analogue

C Biot; N François; L Maciejewski; J Brocard; D Poulain

doi:10.1016/s0960-894x(00)00120-7

Synthesis and antifungal activity of a ferrocene-fluconazole analogue

Bioorg Med Chem Lett. 2000 Apr 17;10(8):839-41. doi: 10.1016/s0960-894x(00)00120-7.

Authors

C Biot¹, N François, L Maciejewski, J Brocard, D Poulain

Affiliation

¹ Laboratoire de Catalyse de Lille, Groupe de Synthèse Organométallique, UPRESA CNRS 8010, Ecole Nationale Supérieure de Chimie de Lille, Villeneuve d'Ascq, France. ch_biot@club-internet.fr

PMID: 10782698
DOI: 10.1016/s0960-894x(00)00120-7

Abstract

A novel ferrocene fluconazole analogue was synthesized and its antifungal properties investigated against yeast strains of medical importance, including those intrinsically resistant to fluconazole. In vitro tests revealed a slight increase in fungal growth and a reversal of the effect of fluconazole at minimal inhibitory concentrations.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / chemical synthesis*
Antifungal Agents / pharmacology*
Candida / drug effects
Ferrous Compounds / chemistry
Ferrous Compounds / pharmacology*
Fluconazole / chemistry
Fluconazole / pharmacology*
Metallocenes
Microbial Sensitivity Tests
Species Specificity

Substances

Antifungal Agents
Ferrous Compounds
Metallocenes
Fluconazole
ferrocene