Immune repopulation after HAART in previously untreated HIV-1-infected children. Paediatric European Network for Treatment of AIDS (PENTA) Steering Committee

Lancet. 2000 Apr 15;355(9212):1331-2. doi: 10.1016/s0140-6736(00)02117-6.

Abstract

In 25 vertically HIV-infected children receiving highly-active antiretroviral therapy, a 3-log10 reduction in plasma HIV RNA load was maintained for 1 year and was associated with a doubling of the CD4-cell percentage. Most (75%) new CD4 cells carried the CD45RA marker of naive cells and there was only a small rise in memory cells (CD45RO). This pattern of immune restoration differs from adults, and may be due to the presence of a functioning thymus in children.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / administration & dosage*
  • Anti-HIV Agents / adverse effects
  • CD4 Lymphocyte Count / drug effects*
  • Child
  • Child, Preschool
  • Dideoxynucleosides / administration & dosage
  • Dideoxynucleosides / adverse effects
  • Dose-Response Relationship, Drug
  • Drug Therapy, Combination
  • Female
  • Follow-Up Studies
  • HIV Infections / drug therapy*
  • HIV Infections / transmission
  • HIV-1 / drug effects*
  • HIV-1 / immunology
  • Humans
  • Immunologic Memory / drug effects
  • Infant
  • Infectious Disease Transmission, Vertical
  • Lamivudine / administration & dosage
  • Lamivudine / adverse effects
  • Male
  • Nelfinavir / administration & dosage
  • Nelfinavir / adverse effects
  • Reverse Transcriptase Inhibitors / administration & dosage*
  • Reverse Transcriptase Inhibitors / adverse effects
  • Treatment Outcome
  • Viral Load
  • Zidovudine / administration & dosage
  • Zidovudine / adverse effects

Substances

  • Anti-HIV Agents
  • Dideoxynucleosides
  • Reverse Transcriptase Inhibitors
  • Lamivudine
  • Zidovudine
  • Nelfinavir
  • abacavir