Abstract
In 25 vertically HIV-infected children receiving highly-active antiretroviral therapy, a 3-log10 reduction in plasma HIV RNA load was maintained for 1 year and was associated with a doubling of the CD4-cell percentage. Most (75%) new CD4 cells carried the CD45RA marker of naive cells and there was only a small rise in memory cells (CD45RO). This pattern of immune restoration differs from adults, and may be due to the presence of a functioning thymus in children.
Publication types
-
Letter
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-HIV Agents / administration & dosage*
-
Anti-HIV Agents / adverse effects
-
CD4 Lymphocyte Count / drug effects*
-
Child
-
Child, Preschool
-
Dideoxynucleosides / administration & dosage
-
Dideoxynucleosides / adverse effects
-
Dose-Response Relationship, Drug
-
Drug Therapy, Combination
-
Female
-
Follow-Up Studies
-
HIV Infections / drug therapy*
-
HIV Infections / transmission
-
HIV-1 / drug effects*
-
HIV-1 / immunology
-
Humans
-
Immunologic Memory / drug effects
-
Infant
-
Infectious Disease Transmission, Vertical
-
Lamivudine / administration & dosage
-
Lamivudine / adverse effects
-
Male
-
Nelfinavir / administration & dosage
-
Nelfinavir / adverse effects
-
Reverse Transcriptase Inhibitors / administration & dosage*
-
Reverse Transcriptase Inhibitors / adverse effects
-
Treatment Outcome
-
Viral Load
-
Zidovudine / administration & dosage
-
Zidovudine / adverse effects
Substances
-
Anti-HIV Agents
-
Dideoxynucleosides
-
Reverse Transcriptase Inhibitors
-
Lamivudine
-
Zidovudine
-
Nelfinavir
-
abacavir