Chlorination of nucleobases, RNA and DNA by myeloperoxidase: a pathway for cytotoxicity and mutagenesis by activated phagocytes

Redox Rep. 1999;4(6):319-20. doi: 10.1179/135100099101535025.

Authors

J P Henderson¹, J Byun, J W Heinecke

Affiliation

¹ Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA.

PMID: 10772075
DOI: 10.1179/135100099101535025

No abstract available

MeSH terms

Cytotoxicity, Immunologic*
Deoxycytidine / analogs & derivatives*
Deoxycytidine / biosynthesis
Deoxycytidine / metabolism
Humans
Mutagenesis
Peroxidase / metabolism*
Phagocytes / metabolism*

Substances

Deoxycytidine
5-chloro-2'-deoxycytidine
Peroxidase