Total synthesis of (+)-amphidinolide P. [corrected]

D R Williams; B J Myers; L Mi

doi:10.1021/ol0000197

Total synthesis of (+)-amphidinolide P. [corrected]

Org Lett. 2000 Apr 6;2(7):945-8. doi: 10.1021/ol0000197.

Authors

D R Williams¹, B J Myers, L Mi

Affiliation

¹ Department of Chemistry, Indiana University, Bloomington 47405-7102, USA. williamd@indiana.edu

PMID: 10768193
DOI: 10.1021/ol0000197

Abstract

The convergent enantiocontrolled total synthesis of the 15-membered macrolactone (-)-amphidinolide P is reported. Key transformations include a Sakurai allylation, a Stille coupling for the formation of a fully functionalized acyclic precursor, and intramolecular transesterification.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Antineoplastic Agents / chemical synthesis*
Dinoflagellida / chemistry*
Heterocyclic Compounds / chemical synthesis*
Indicators and Reagents
Macrolides

Substances

Antineoplastic Agents
Heterocyclic Compounds
Indicators and Reagents
Macrolides
amphidinolide P

Grants and funding

GM-42897/GM/NIGMS NIH HHS/United States