Abstract
Two 1,2,3,4-tetrahydoquinoline-based compounds were synthesized and evaluated for antinociceptive properties. Both compounds displayed no significant analgesic activity and at the higher dose showed no characterized CNS depressant activity.
MeSH terms
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Analgesics / chemical synthesis*
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Analgesics / chemistry
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Analgesics / pharmacology*
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Animals
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Magnetic Resonance Spectroscopy
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Neurokinin-1 Receptor Antagonists
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Quinolines / chemical synthesis*
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Quinolines / chemistry
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Quinolines / pharmacology*
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Rats
Substances
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2-butyl-1,2,3,4-tetrahydro-5-quinolinol
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2-methyl-1,2,3,4-tetrahydroquinoline-5-methanol
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Analgesics
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Neurokinin-1 Receptor Antagonists
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Quinolines