PPAR delta functions as a prostacyclin receptor in blastocyst implantation

H Lim; S K Dey

doi:10.1016/s1043-2760(00)00243-5

PPAR delta functions as a prostacyclin receptor in blastocyst implantation

Trends Endocrinol Metab. 2000 May-Jun;11(4):137-42. doi: 10.1016/s1043-2760(00)00243-5.

Authors

H Lim¹, S K Dey

Affiliation

¹ Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, 20 Shattuck Street, Thorn 1010, Boston, MA 02115, USA.

PMID: 10754535
DOI: 10.1016/s1043-2760(00)00243-5

Abstract

Peroxisome proliferator-activated receptors (PPARs), members of the nuclear hormone superfamily, are the target of extensive investigation because of their role in various pathophysiological processes. Recently, a novel biological function of PPAR delta, a less studied member of the family, was observed in the mouse. Evidence suggests that cyclooxygenase 2-derived prostacyclin mediates blastocyst implantation via this receptor. In this review, this new function of PPAR delta in implantation is highlighted, and future directions to investigate its mechanism of action are discussed.

Publication types

Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Blastocyst / physiology*
Embryo Implantation / physiology*
Prostaglandins / physiology
Receptors, Cell Surface / physiology
Receptors, Cytoplasmic and Nuclear / physiology*
Receptors, Epoprostenol
Receptors, Prostaglandin / physiology*
Signal Transduction / physiology
Transcription Factors / physiology*

Substances

Prostaglandins
Receptors, Cell Surface
Receptors, Cytoplasmic and Nuclear
Receptors, Epoprostenol
Receptors, Prostaglandin
Transcription Factors

Abstract

Publication types

MeSH terms

Substances

Grants and funding