Abstract
A rare case of mixed follicular-parafollicular thyroid carcinoma which occurred in a 50-year-old man, is reported. The ultrastructural aspects of the tumor showed: a biphasic growth pattern with microfolliculi and solid areas; the coexpression of thyroglobulin and calcitonin antigens in the same follicle-like structures; the presence of neuroendocrine granules, microvilli and intracytoplasmic canaliculi bordered by microvilli. These characteristics lead us to a diagnosis of mixed follicular-parafollicular thyroid carcinoma.
MeSH terms
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Adenocarcinoma, Follicular / drug therapy
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Adenocarcinoma, Follicular / pathology*
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Adenocarcinoma, Follicular / surgery
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Calcitonin / analysis
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Carcinoma, Medullary / drug therapy
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Carcinoma, Medullary / pathology*
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Carcinoma, Medullary / surgery
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Cell Division
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Cytoplasmic Granules / pathology
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Fatal Outcome
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Humans
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Male
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Microvilli / pathology
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Middle Aged
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Neoplasms, Second Primary / drug therapy
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Neoplasms, Second Primary / pathology*
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Neoplasms, Second Primary / surgery
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Palliative Care
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Thyroglobulin / analysis
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Thyroid Neoplasms / drug therapy
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Thyroid Neoplasms / pathology*
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Thyroid Neoplasms / surgery