Mixed follicular and parafollicular thyroid carcinoma

J Exp Clin Cancer Res. 1999 Dec;18(4):567-9.

Abstract

A rare case of mixed follicular-parafollicular thyroid carcinoma which occurred in a 50-year-old man, is reported. The ultrastructural aspects of the tumor showed: a biphasic growth pattern with microfolliculi and solid areas; the coexpression of thyroglobulin and calcitonin antigens in the same follicle-like structures; the presence of neuroendocrine granules, microvilli and intracytoplasmic canaliculi bordered by microvilli. These characteristics lead us to a diagnosis of mixed follicular-parafollicular thyroid carcinoma.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma, Follicular / drug therapy
  • Adenocarcinoma, Follicular / pathology*
  • Adenocarcinoma, Follicular / surgery
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Calcitonin / analysis
  • Carcinoma, Medullary / drug therapy
  • Carcinoma, Medullary / pathology*
  • Carcinoma, Medullary / surgery
  • Cell Division
  • Cytoplasmic Granules / pathology
  • Fatal Outcome
  • Humans
  • Male
  • Microvilli / pathology
  • Middle Aged
  • Neoplasms, Second Primary / drug therapy
  • Neoplasms, Second Primary / pathology*
  • Neoplasms, Second Primary / surgery
  • Palliative Care
  • Thyroglobulin / analysis
  • Thyroid Neoplasms / drug therapy
  • Thyroid Neoplasms / pathology*
  • Thyroid Neoplasms / surgery

Substances

  • Calcitonin
  • Thyroglobulin