RNA folding at elementary step resolution

RNA. 2000 Mar;6(3):325-38. doi: 10.1017/s1355838200992161.

Abstract

We study the stochastic folding kinetics of RNA sequences into secondary structures with a new algorithm based on the formation, dissociation, and the shifting of individual base pairs. We discuss folding mechanisms and the correlation between the barrier structure of the conformational landscape and the folding kinetics for a number of examples based on artificial and natural sequences, including the influence of base modification in tRNAs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Algorithms
  • Base Sequence
  • Energy Transfer
  • Kinetics
  • Molecular Sequence Data
  • Nucleic Acid Conformation*
  • RNA / chemistry*
  • RNA / metabolism*
  • RNA, Transfer, Phe / chemistry
  • RNA, Transfer, Phe / metabolism
  • Thermodynamics

Substances

  • RNA, Transfer, Phe
  • RNA