A series of 3456 patients with malignant tumours of the maxillofacial region have been treated at the Clinic for Maxillofacial and Oral Surgery of the Military Medical Academy, Stomatological Clinic of the M.M.A. and Radiological Institute of Medical Faculty in Belgrade. The most frequent localization was lips and mucosa of the oral cavity, 77,9%. The irradiation therapy was applied in 42,3% of the patients and combined surgery and irradiation therapy in 28,6% Postirradiation changes of the oral cavity mucosa were found in 25% of the patients, teeth changes in 50% and Candida albicans was found in 56% of the patients. In order to prevent irradiation and postirradiation complications, all the patients with malignant tumours foressen for irradiation therapy should undergo a detailed stomatological examination and sanation of the oral cavity and teeth. The authors advocate team work in establishing the diagnosis and treating in which an important place should have stomatologist.