Abstract
The activity of a novel series of peptidomimetic hematoregulatory compounds, designed based on a pharmacophore model inferred from the structure activity relationships of a peptide SK&F 107647 (1), is reported. These compounds induce a hematopoietic synergistic factor (HSF) which in turn modulates host defense. The compounds may represent novel therapeutic agents in the area of hematoregulation.
MeSH terms
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Amino Acids / chemistry
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Animals
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Candidiasis / drug therapy
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Cardiovascular Agents / chemical synthesis*
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Cardiovascular Agents / pharmacology
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Cardiovascular Agents / therapeutic use
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Cell Line
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Chemokine CXCL1
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Chemokines, CXC*
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Chemotactic Factors / metabolism
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Drug Design
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Granulocyte Colony-Stimulating Factor / biosynthesis
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Granulocyte-Macrophage Colony-Stimulating Factor / biosynthesis
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Growth Substances / metabolism
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Intercellular Signaling Peptides and Proteins*
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Macrophage Colony-Stimulating Factor / biosynthesis
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Mice
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Oligopeptides / chemistry
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Oligopeptides / pharmacology*
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Receptors, Drug / chemistry
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Receptors, Drug / drug effects
Substances
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Amino Acids
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Cardiovascular Agents
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Chemokine CXCL1
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Chemokines, CXC
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Chemotactic Factors
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Cxcl1 protein, mouse
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Growth Substances
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Intercellular Signaling Peptides and Proteins
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Oligopeptides
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Receptors, Drug
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Granulocyte Colony-Stimulating Factor
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SK&F 107647
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Macrophage Colony-Stimulating Factor
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Granulocyte-Macrophage Colony-Stimulating Factor