Functional derivatives of 5-benzo[1, 3]dioxol-5-yl-1-methyl-1H-imidazole-2-carbaldehyde and evaluation of leishmanicidal activity

P Vanelle; J Meuche; J Maldonado; M P Crozet; F Delmas; P Timon-David

doi:10.1016/s0223-5234(00)00106-9

Functional derivatives of 5-benzo[1, 3]dioxol-5-yl-1-methyl-1H-imidazole-2-carbaldehyde and evaluation of leishmanicidal activity

Eur J Med Chem. 2000 Jan;35(1):157-62. doi: 10.1016/s0223-5234(00)00106-9.

Authors

P Vanelle¹, J Meuche, J Maldonado, M P Crozet, F Delmas, P Timon-David

Affiliation

¹ Laboratoire de chimie organique, faculté de pharmacie, 27, boulevard J. Moulin, 13385, Marseille, France. patrice.vanelle@pharmacie.univ.mrs.fr

PMID: 10733612
DOI: 10.1016/s0223-5234(00)00106-9

Abstract

New imidazole derivatives were obtained after subjecting 5-benzo[1, 3]dioxol-5-yl-1-methyl-1H-imidazole-2-carbaldehyde to a Knoevenagel reaction. Some of these compounds exhibit significant in vitro leishmanicidal activity.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Acrylamides / chemical synthesis*
Acrylamides / pharmacology*
Animals
Imidazoles / chemical synthesis*
Imidazoles / pharmacology*
Leishmania infantum / drug effects*
Molecular Structure
Structure-Activity Relationship

Substances

3-(5-benzo(1,3)dioxol-5-yl-1-methyl-1H-imidazol-2-yl)-2-nitroacrylamide
Acrylamides
Imidazoles