HXB/Ipcv and BXH/Cub recombinant inbred strains of the rat: strain distribution patterns of 632 alleles

M Pravenec; V Kren; D Krenová; V Bíla; V Zídek; M Simáková; A Musilová; H A van Lith; L F van Zutphen

HXB/Ipcv and BXH/Cub recombinant inbred strains of the rat: strain distribution patterns of 632 alleles

Folia Biol (Praha). 1999;45(5):203-15.

Authors

M Pravenec¹, V Kren, D Krenová, V Bíla, V Zídek, M Simáková, A Musilová, H A van Lith, L F van Zutphen

Affiliation

¹ Institute of Physiology, Academy of Sciences of the Czech Republic, Prague. pravenec@biomed.cas.cz

PMID: 10730889

Abstract

The HXB/Ipcv and BXH/Cub sets of recombinant inbred (RI) strains were derived from the spontaneously hypertensive rats (SHR/OlaIpcv) and normotensive Brown Norway (BN-Lx/Cub) rats. The RI strains were produced as a model system for genetic and correlation analysis of spontaneous hypertension and other risk factors of cardiovascular disease such as insulin resistance and dyslipidemia. The RI strains were phenotyped in multiple hemodynamic and metabolic traits. In the current study, we describe strain distribution patterns of 632 genetic markers.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles*
Animals
Cardiovascular Diseases / genetics
Genetic Markers
Genetic Predisposition to Disease
Rats
Rats, Inbred BN / genetics*
Rats, Inbred SHR / genetics*
Rats, Inbred Strains / genetics*
Recombination, Genetic
Risk Factors
Species Specificity

Substances

Genetic Markers