The activation of B-Raf and Raf-1 after electroconvulsive shock in the rat hippocampus

U G Kang; S H Jeon; J E Lee; Y H Joo; J S Yi; J B Park; Y S Juhnn; Y S Kim

doi:10.1016/s0028-3908(99)00184-7

The activation of B-Raf and Raf-1 after electroconvulsive shock in the rat hippocampus

Neuropharmacology. 2000 Feb 14;39(4):703-6. doi: 10.1016/s0028-3908(99)00184-7.

Authors

U G Kang¹, S H Jeon, J E Lee, Y H Joo, J S Yi, J B Park, Y S Juhnn, Y S Kim

Affiliation

¹ Department of Psychiatry, Seoul National University College of Medicine, South Korea.

PMID: 10728891
DOI: 10.1016/s0028-3908(99)00184-7

Abstract

We demonstrated that ECS activates the kinase activity of B-Raf and Raf-1 in the rat hippocampus. The activity was maximal at one minute after ECS and temporally coincided with the increased membrane translocation of Rafs and the reported activity of MAPK, but not with the phosphorylation of Rafs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Biological Transport
Cell Membrane / metabolism
Electroshock
Hippocampus / enzymology*
Hippocampus / metabolism
Immunoblotting
Male
Phosphorylation
Proto-Oncogene Proteins c-raf / metabolism*
Rats
Rats, Sprague-Dawley

Substances

Proto-Oncogene Proteins c-raf