Intrapartum tocolysis has no effect on fetal lactate concentration

Eur J Obstet Gynecol Reprod Biol. 2000 Apr;89(2):165-8. doi: 10.1016/s0301-2115(99)00211-0.

Abstract

Objective: To assess the fetal metabolic effects of intrapartum maternal tocolysis with terbutaline in the presence of fetal heart rate abnormalities, with a special emphasis on lactate concentration, in view of its potential use as a marker of fetal condition.

Design: Descriptive study.

Setting: Two labour wards, National University Hospital, Singapore, and Ostersund Hospital, Sweden.

Methods: Eight parturients with abnormal intrapartum fetal heart rate recordings were given bolus i.v. injection of 0.25 mg terbutaline and monitored both before and 20 minutes after treatment.

Results: Maternal venous glucose increased from 5.0 (0.9) (mean (SD)) to 5.6 (1.2) mmol/l (p=0.002) and fetal scalp blood glucose rose from 4.1 (1.8) to 4.7 (1.4) mmol/l (p=0.009) 20 minutes after the injection. No significant change was found in maternal or fetal lactate concentrations.

Conclusion: Terbutaline tocolysis for "intrauterine resuscitation" does not affect fetal lactate concentration 20 minutes after treatment.

MeSH terms

  • Acid-Base Equilibrium
  • Adult
  • Blood Glucose / analysis
  • Female
  • Fetus / metabolism*
  • Heart Rate, Fetal
  • Humans
  • Hydrogen-Ion Concentration
  • Lactic Acid / blood*
  • Pregnancy
  • Terbutaline / pharmacology*
  • Tocolysis*

Substances

  • Blood Glucose
  • Lactic Acid
  • Terbutaline