Abstract
The entry of tetanus neurotoxin into neuronal cells proceeds through the initial binding of the toxin to gangliosides on the cell surface. The carboxyl-terminal fragment of the heavy chain of tetanus neurotoxin contains the ganglioside-binding site, which has not yet been fully characterized. The crystal structures of native H(C) and of H(C) soaked with carbohydrates reveal a number of binding sites and provide insight into the possible mode of ganglioside binding.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylgalactosamine / chemistry
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Binding Sites
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Carbohydrates / chemistry*
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Crystallography, X-Ray
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Galactose / chemistry
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Gangliosides / metabolism*
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Lactose / chemistry
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Models, Molecular
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N-Acetylneuraminic Acid / chemistry
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Peptide Fragments / chemistry*
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Protein Binding
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Tetanus Toxin / chemistry*
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Tetanus Toxin / metabolism
Substances
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Carbohydrates
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Gangliosides
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Peptide Fragments
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Tetanus Toxin
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N-Acetylneuraminic Acid
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Lactose
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Acetylgalactosamine
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Galactose
Associated data
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PDB/1D0H
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PDB/1DFQ
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PDB/1DIW
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PDB/1DLL