Antihypertensive activity of substituted 2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridinedicarboxylate enantiomers

E Martín; A Morán; M L Martín; L San Román; P Puebla; M Medarde; E Caballero; A San Feliciano

doi:10.1016/s0960-894x(99)00691-5

Antihypertensive activity of substituted 2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridinedicarboxylate enantiomers

Bioorg Med Chem Lett. 2000 Feb 21;10(4):319-22. doi: 10.1016/s0960-894x(99)00691-5.

Authors

E Martín¹, A Morán, M L Martín, L San Román, P Puebla, M Medarde, E Caballero, A San Feliciano

Affiliation

¹ Laboratorio de Farmacología, Facultad de Farmacia, Universidad de Salamanca, Spain.

PMID: 10714490
DOI: 10.1016/s0960-894x(99)00691-5

Abstract

The synthesis and antihypertensive activity of racemates and enantiomers of substituted 2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridinedicarboxylates have been reported.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antihypertensive Agents / chemistry*
Antihypertensive Agents / pharmacokinetics
Antihypertensive Agents / therapeutic use*
Blood Pressure / drug effects
Drug Evaluation
Heart Rate / drug effects
Male
Nifedipine / pharmacokinetics
Nifedipine / therapeutic use
Oxazoles / chemistry*
Oxazoles / pharmacokinetics
Oxazoles / therapeutic use*
Pyridines / chemistry*
Pyridines / pharmacokinetics
Pyridines / therapeutic use*
Rats
Rats, Inbred SHR
Stereoisomerism
Structure-Activity Relationship
Time Factors

Substances

Antihypertensive Agents
Oxazoles
Pyridines
Nifedipine