Cytochrome c release from mitochondria: all or nothing

Nat Cell Biol. 2000 Mar;2(3):E41-3. doi: 10.1038/35004069.

Abstract

During the process of apoptosis, cytochrome c is released from mitochondria into the cytosol where it helps to activate the caspases, a family of killer proteases. The release of cytochrome c is a rapid, complete and kinetically invariant event.

Publication types

  • Comment
  • News

MeSH terms

  • Apoptosis*
  • Caspases / metabolism
  • Cell Line
  • Cell Membrane Permeability / physiology
  • Cytochrome c Group / metabolism*
  • Cytosol / enzymology*
  • HeLa Cells
  • Humans
  • Intracellular Membranes / enzymology
  • Mitochondria / enzymology*
  • Models, Biological

Substances

  • Cytochrome c Group
  • Caspases