Voltammetric study and determination of buprenorphine in pharmaceuticals

J Pharm Biomed Anal. 1999 Dec;21(4):809-15. doi: 10.1016/s0731-7085(99)00193-4.

Abstract

The oxidation of buprenorphine on a carbon paste electrode has been studied using voltammetric techniques under both semi-infinite linear diffusion and hydrodynamic conditions. By applying a simple electrode pretreatment a good reproducibility of the current signal is obtained (R.S.D. = 0.85%, n = 6 for a 1.0 x 10(-5) M buprenorphine concentration). The limit of detection was found to be 2.0 x 10(-7) M. The voltammetric method developed for the determination of buprenorphine in pharmaceutical preparations was examined for its applicability to liquid and solid preparations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analgesics, Opioid / analysis*
  • Buprenorphine / analysis*
  • Diffusion
  • Electrochemistry / methods
  • Electrodes
  • Hydrogen-Ion Concentration
  • Oxidation-Reduction
  • Pharmaceutical Preparations / analysis*
  • Quality Control
  • Reproducibility of Results
  • Surface Properties

Substances

  • Analgesics, Opioid
  • Pharmaceutical Preparations
  • Buprenorphine