Recombinant calcium channel is recognized by Lambert-Eaton myasthenic syndrome antibodies

K Iwasa; M Takamori; K Komai; Y Mori

doi:10.1212/wnl.54.3.757

Recombinant calcium channel is recognized by Lambert-Eaton myasthenic syndrome antibodies

Neurology. 2000 Feb 8;54(3):757-9. doi: 10.1212/wnl.54.3.757.

Authors

K Iwasa¹, M Takamori, K Komai, Y Mori

Affiliation

¹ Department of Neurology, Kanazawa University School of Medicine, Japan.

PMID: 10680821
DOI: 10.1212/wnl.54.3.757

Abstract

The authors studied sera from 36 patients with Lambert-Eaton myasthenic syndrome (LEMS) by immunoblots using the recombinant protein derived from the DNA sequence encoding for the domain III S5-S6 linker of the P/Q-type voltage-gated calcium channel al subunit. The results of 18 patients were positive for antibodies to this recombinant protein. The results of 2 of 10 patients with lung cancer without LEMS were also positive.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies / immunology*
Calcium Channels / immunology*
Humans
Immunoblotting
Myasthenia Gravis / immunology*
Recombinant Proteins / immunology*
Syndrome

Substances

Antibodies
Calcium Channels
Recombinant Proteins