Abstract
In Central America aerial parts of the Asteraceae Milleria quinqueflora are used in traditional medicine as a remedy for skin infections. Reinvestigation of this plant afforded thirteen sesquiterpene lactones (Sls), three of them are new. All isolated Sls were studied for their anti-inflammatory activity using the transcription factor NF-kappa B as molecular target. NF-kappa B is involved in the synthesis of inflammatory mediators, such as cytokines and chemokines. NF-kappa B DNA binding was inhibited at micromolar concentrations by all Sls.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Inflammatory Agents, Non-Steroidal / chemistry*
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Asteraceae / chemistry*
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Central America
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Humans
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Jurkat Cells
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Lactones / chemistry
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Lactones / isolation & purification
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Lactones / pharmacology
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Medicine, Traditional
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Models, Molecular
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Molecular Conformation
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Molecular Structure
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NF-kappa B / antagonists & inhibitors*
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Phytotherapy
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Plants, Medicinal*
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Sesquiterpenes / chemistry*
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Lactones
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NF-kappa B
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Sesquiterpenes