Study of sesquiterpene lactones from Milleria quinqueflora on their anti-inflammatory activity using the transcription factor NF-kappa B as molecular target

Phytochemistry. 2000 Jan;53(2):257-63. doi: 10.1016/s0031-9422(99)00510-5.

Abstract

In Central America aerial parts of the Asteraceae Milleria quinqueflora are used in traditional medicine as a remedy for skin infections. Reinvestigation of this plant afforded thirteen sesquiterpene lactones (Sls), three of them are new. All isolated Sls were studied for their anti-inflammatory activity using the transcription factor NF-kappa B as molecular target. NF-kappa B is involved in the synthesis of inflammatory mediators, such as cytokines and chemokines. NF-kappa B DNA binding was inhibited at micromolar concentrations by all Sls.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / chemistry*
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Asteraceae / chemistry*
  • Central America
  • Humans
  • Jurkat Cells
  • Lactones / chemistry
  • Lactones / isolation & purification
  • Lactones / pharmacology
  • Medicine, Traditional
  • Models, Molecular
  • Molecular Conformation
  • Molecular Structure
  • NF-kappa B / antagonists & inhibitors*
  • Phytotherapy
  • Plants, Medicinal*
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Lactones
  • NF-kappa B
  • Sesquiterpenes