Abstract
In most cells, the structure of the actin cytoskeleton is regulated by Rho-family G proteins. Recent work has outlined a highly conserved signaling pathway from G protein activation to actin assembly. The key downstream components are WASP family proteins - adaptor molecules that bind multiple signaling and cytoskeletal proteins - and the Arp2/3 complex - a multi-functional protein complex that nucleates and crosslinks actin filaments.
MeSH terms
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Actin Cytoskeleton / chemistry
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Actin Cytoskeleton / metabolism
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Actin-Related Protein 2
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Actin-Related Protein 3
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Actins / metabolism*
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Animals
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Biopolymers / metabolism
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Cell Polarity
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Cytoskeletal Proteins*
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Cytoskeleton / chemistry
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Cytoskeleton / metabolism*
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Humans
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Proteins / genetics
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Proteins / metabolism*
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Signal Transduction*
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Wiskott-Aldrich Syndrome Protein
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rho GTP-Binding Proteins / metabolism
Substances
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ACTR2 protein, human
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ACTR3 protein, human
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Actin-Related Protein 2
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Actin-Related Protein 3
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Actins
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Biopolymers
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Cytoskeletal Proteins
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Proteins
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WAS protein, human
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Wiskott-Aldrich Syndrome Protein
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rho GTP-Binding Proteins