Abstract
The solid phase synthesis of a set of peptide aldehydes derived from the NS5A/NS5B junction of hepatitis C virus (HCV) viral polyprotein is demonstrated using an oxazolidine linker and the Multipin method. Deletion of the P6 and P5 residues results in a dramatic loss of inhibitory activity.
MeSH terms
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Aldehydes / chemical synthesis*
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Endopeptidases / metabolism
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Hepacivirus / chemistry*
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Models, Chemical
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Peptides / chemical synthesis*
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Polyproteins / chemistry*
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Protease Inhibitors / chemical synthesis*
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Spectrophotometry
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Viral Nonstructural Proteins / antagonists & inhibitors*
Substances
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Aldehydes
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NS3 protein, hepatitis C virus
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Peptides
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Polyproteins
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Protease Inhibitors
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Viral Nonstructural Proteins
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NS-5 protein, hepatitis C virus
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Endopeptidases