Abstract
Synchronous cancers of the oesophagus and stomach diagnosed in a patient showing pronounced leucocytosis were examined for production of granulocyte colony stimulating factor (G-CSF) and expression of G-CSF receptor. Whereas enzyme immunoassay of tissue extracts showed that the oesophageal carcinoma produced G-CSF, the gastric cancer did not. However, the gastric tumour showed G-CSF receptor expression on immunohistochemical examination of sections. These findings suggest that the oesophageal cancer promoted gastric cancer growth by paracrine mechanisms involving G-CSF.
MeSH terms
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Adenocarcinoma / etiology*
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Adenocarcinoma / metabolism
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Aged
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Carcinoma, Squamous Cell / complications*
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Carcinoma, Squamous Cell / metabolism
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Esophageal Neoplasms / complications*
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Esophageal Neoplasms / metabolism
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Granulocyte Colony-Stimulating Factor / metabolism
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Humans
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Male
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Neoplasm Proteins / metabolism
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Neoplasms, Multiple Primary* / metabolism
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Receptors, Granulocyte Colony-Stimulating Factor / metabolism
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Stomach Neoplasms / etiology*
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Stomach Neoplasms / metabolism
Substances
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Neoplasm Proteins
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Receptors, Granulocyte Colony-Stimulating Factor
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Granulocyte Colony-Stimulating Factor