Cationic Phosphonolipids Containing Quaternary Phosphonium and Arsonium Groups for DNA Transfection with Good Efficiency and Low Cellular Toxicity**

E Guénin; AC Hervé; V Floch V; S Loisel; JJ Yaouanc; JC Clément; C Férec; des Abbayes H

Cationic Phosphonolipids Containing Quaternary Phosphonium and Arsonium Groups for DNA Transfection with Good Efficiency and Low Cellular Toxicity**

Angew Chem Int Ed Engl. 2000 Feb;39(3):629-631.

Authors

E Guénin¹, AC Hervé, V Floch V, S Loisel, JJ Yaouanc, JC Clément, C Férec, des Abbayes H

Affiliation

¹ UMR CNRS 6521, Université de Bretagne Occidentale Département de Chimie 6, avenue Le Gorgeu, BP 809, 29285 Brest Cedex (France).

PMID: 10671280

Abstract

Replacing the ammonium polar head in cationic lipids 1 (A=N) by a phosphonium or an arsonium group (A=P, As) improves their properties as synthetic vectors for DNA transfection. The increased volume of the cationic head is supposed to modify the interactions of the vector with the solvent and DNA.