Electrospray multistep ion trap mass spectrometry for the structural characterisation of poly

G Adamus; M Kowalczuk

doi:10.1002/(SICI)1097-0231(20000229)14:4<195::AID-RCM864>3.0.CO;2-X

Electrospray multistep ion trap mass spectrometry for the structural characterisation of poly

Rapid Commun Mass Spectrom. 2000;14(4):195-202. doi: 10.1002/(SICI)1097-0231(20000229)14:4<195::AID-RCM864>3.0.CO;2-X.

Authors

G Adamus¹, M Kowalczuk

Affiliation

¹ Polish Academy of Sciences, Centre for Polymer Chemistry, 41-800 Zabrze, Poland.

PMID: 10669876
DOI: 10.1002/(SICI)1097-0231(20000229)14:4<195::AID-RCM864>3.0.CO;2-X

Abstract

Electrospray 'soft' ionisation (ESI) and multistep mass spectrometry (MS(n)) techniques enable characterisation of a bioactive polymer, poly[(R,S)-3-hydroxybutanoic acid] (a-PHB), containing covalently bonded benzylpenicillin. The chemical structures of individual mass-selected bioactive macromolecules have been determined, and their fragmentation mechanisms have been compared with those of pure penicillin G. Copyright 2000 John Wiley & Sons, Ltd.