Abstract
Novel toluidine derivatives are described. Some of them showed an interesting in vitro activity against Mycobacterium tuberculosis, M. smegmatis, M. marinum, M. gordonae, and M. avium. Some of them were more active than Streptomycin and Isoniazid, which were used as controls, against M. avium and M. gordonae. In particular, we confirm the good activity of biphenyl derivatives.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Chlorocebus aethiops
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Magnetic Resonance Spectroscopy
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Microbial Sensitivity Tests
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Mycobacterium / drug effects*
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Species Specificity
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Spectrophotometry, Infrared
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Toluidines / chemistry
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Toluidines / pharmacology*
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Vero Cells
Substances
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Anti-Bacterial Agents
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Toluidines