Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene

Genomics. 2000 Jan 1;63(1):133-8. doi: 10.1006/geno.1999.6045.

Abstract

The genomic sequence of the human Jagged2 (JAG2) gene, which encodes a ligand for the Notch receptors, was determined. The 30-kb DNA sequence spanning the JAG2 gene contains 26 exons and a putative promoter region. Several potential binding sites for transcription factors, including NF-kappab, E47, E12, E2F, Ets-1, MyoD, and OCT-1, were found in the human JAG2 promoter region. The JAG2 gene was also mapped to the chromosomal region 14q32 using fluorescence in situ hybridization.

MeSH terms

  • Base Sequence
  • Blotting, Northern
  • Carrier Proteins / genetics*
  • Carrier Proteins / metabolism
  • Chromosome Mapping
  • Chromosomes, Human, Pair 14*
  • Humans
  • In Situ Hybridization, Fluorescence
  • Intercellular Signaling Peptides and Proteins
  • Jagged-2 Protein
  • Ligands
  • Membrane Proteins / metabolism
  • Molecular Sequence Data
  • Organ Specificity
  • Polymerase Chain Reaction
  • Receptors, Notch
  • Sequence Analysis, DNA

Substances

  • Carrier Proteins
  • Intercellular Signaling Peptides and Proteins
  • JAG2 protein, human
  • Jagged-2 Protein
  • Ligands
  • Membrane Proteins
  • Receptors, Notch

Associated data

  • GENBANK/AF029778
  • GENBANK/AF111170