Recombinant bacillus Calmette-Guérin as a potential vector for preventive HIV type 1 vaccines

AIDS Res Hum Retroviruses. 2000 Jan 20;16(2):91-8. doi: 10.1089/088922200309421.

Abstract

In August 1997, the World Health Organization (WHO) and the Joint United Nations Programme on HIV/AIDS (UNAIDS) convened an expert working group to discuss current strategies for the development of HIV type 1 vaccines. Based on the recent findings of investigators from Japan's National Institute of Infectious Diseases (NIID) in Tokyo using recombinant bacillus Calmette-Guérin (rBCG) as a potential vectored vaccine for HIV, a recommendation was made that further work in this area is a priority. As a result, the working group reconvened in September 1998 to discuss the progress to date with this vaccine approach, as well as areas of related research to assess the feasibility of a BCG-vectored HIV vaccine. This report summarizes the discussions addressing the available scientific data on the potential use of rBCG as a vector for preventive HIV vaccines, the work necessary to move such candidate vaccines into Phase 1 clinical trials, and recommendations targeted at facilitating the long-term development of rBCG-vectored HIV vaccines.

Publication types

  • Congress

MeSH terms

  • AIDS Vaccines* / immunology
  • Animals
  • BCG Vaccine* / immunology
  • Clinical Trials, Phase I as Topic
  • Genetic Vectors
  • HIV Infections / immunology
  • HIV Infections / prevention & control*
  • HIV-1 / immunology*
  • Humans
  • United Nations
  • Vaccines, Synthetic* / immunology
  • World Health Organization

Substances

  • AIDS Vaccines
  • BCG Vaccine
  • Vaccines, Synthetic