Fluorodopa uptake and glucose metabolism in early stages of corticobasal degeneration

J Neurol. 1999 Dec;246(12):1151-8. doi: 10.1007/s004150050534.

Abstract

Fluorodopa (FDOPA) and fluorodeoxyglucose (FDG) PET was performed in six patients in early stages of corticobasal degeneration (CBD) and compared to Parkinson's disease (PD) patients with a similar degree of bradykinesia and rigidity and to healthy controls. Statistical parametric mapping analysis comparing CBD to controls showed metabolic decrease in premotor, primary motor, supplementary motor, primary sensory, prefrontal, and parietal associative cortices, and in caudate and thalamus contralateral to the side of clinical signs. Except for the prefrontal regions a similar metabolic pattern was observed when CBD was compared to PD. Putamen FDOPA uptake was decreased in both CBD and PD. Caudate FDOPA uptake in CBD patients was decreased contralateral to clinical signs when compared to controls, but was higher than in PD. In early stages of CBD, FDOPA and FDG PET patterns differed from those observed in PD. In CBD the asymmetry in FDOPA uptake was less pronounced than that of clinical signs or metabolic impairment.

Publication types

  • Case Reports
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Basal Ganglia / diagnostic imaging
  • Basal Ganglia / metabolism*
  • Brain Diseases / diagnostic imaging
  • Brain Diseases / metabolism*
  • Cerebral Cortex / diagnostic imaging
  • Cerebral Cortex / metabolism*
  • Dihydroxyphenylalanine / analogs & derivatives*
  • Dihydroxyphenylalanine / pharmacokinetics
  • Female
  • Fluorodeoxyglucose F18 / pharmacokinetics
  • Glucose / metabolism*
  • Humans
  • Male
  • Middle Aged
  • Nerve Degeneration / diagnostic imaging
  • Nerve Degeneration / metabolism*
  • Parkinson Disease / diagnostic imaging
  • Parkinson Disease / metabolism
  • Radiopharmaceuticals / pharmacokinetics
  • Reference Values
  • Tissue Distribution
  • Tomography, Emission-Computed

Substances

  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18
  • fluorodopa F 18
  • Dihydroxyphenylalanine
  • Glucose