Herbacic acid, a simple prototype of 5,5,5-trichloroleucine metabolites from the sponge Dysidea herbacea

J Nat Prod. 2000 Jan;63(1):155-7. doi: 10.1021/np990468j.

Abstract

Dysidea herbacea, collected at Harrier Reef on the Great Barrier Reef, contains the novel metabolite herbacic acid as the major trichloroleucine metabolite. Herbacic acid appears to be an early product of direct free-radical chlorination of leucine and is a prototype for further transformation of the free carboxylic acid group and generation of complex trichloromethyl metabolites, including natural products of the dysidenin family.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acids / chemistry
  • Amino Acids / isolation & purification*
  • Animals
  • Leucine / analogs & derivatives*
  • Molecular Structure
  • Porifera / chemistry*
  • Spectrum Analysis

Substances

  • Amino Acids
  • herbacic acid
  • Leucine