Effects of MS-8209, an amphotericin B derivative, on tumor necrosis factor alpha synthesis and human immunodeficiency virus replication in macrophages

Antimicrob Agents Chemother. 2000 Feb;44(2):405-7. doi: 10.1128/AAC.44.2.405-407.2000.

Abstract

Amphotericin B derivatives, such as MS-8209, have been evaluated as a therapeutic approach to human immunodeficiency virus (HIV) infection. We show that MS-8209, like amphotericin B, increases tumor necrosis factor alpha (TNF-alpha) mRNA expression and TNF-alpha production and consequently HIV replication in human macrophages. These effects confirm the pharmacological risk associated with the administration of amphotericin B or its derivatives to HIV-infected patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphotericin B / analogs & derivatives*
  • Amphotericin B / pharmacology
  • Anti-HIV Agents / pharmacology*
  • HIV / drug effects*
  • HIV / physiology
  • Humans
  • Macrophages / metabolism
  • Macrophages / virology*
  • RNA, Messenger / biosynthesis
  • Risk Factors
  • Tumor Necrosis Factor-alpha / biosynthesis*
  • Tumor Necrosis Factor-alpha / drug effects
  • Virus Replication / drug effects

Substances

  • Anti-HIV Agents
  • RNA, Messenger
  • Tumor Necrosis Factor-alpha
  • MS 8209
  • Amphotericin B