Objective: to study the influence of serologically diagnosed chronic infection with Chlamydia pneumoniae on the progression of lower limb atherosclerosis in a group of disposed men.
Material and methods: the highest systolic brachial and lowest systolic ankle blood pressures were followed for an average of 2.7 years in 129 men aged 65-73 years with conservatively treated small abdominal aortic aneurysms. Blood samples were taken to measure low-density lipoprotein and IgA and IgG titres of antibodies against C. pneumoniae by a microimmunofluorescence test.
Results: the prevalences of seropositivity varied from 43 to 83% depending on the definition. The ankle-brachial blood pressure index of the IgA-seropositive [corrected] men decreases by 11%, while it decreased by 4.8% among IgA-seronegative men (p<0.05). The significant difference persisted in a multiple-regression analysis adjusting for age, smoking, initial systolic ankle BP, and initial brachial systolic or diastolic BP, but disappeared after adjusting for the level of low-density lipoprotein.
Conclusions: C. pneumoniae infection is associated with the progression of atherosclerosis.
Copyright 1999 Harcourt Publishers Ltd.