Isoferulic acid as active principle from the rhizoma of Cimicifuga dahurica to lower plasma glucose in diabetic rats

I M Liu; T C Chi; F L Hsu; C F Chen; J T Cheng

doi:10.1055/s-1999-14048

Isoferulic acid as active principle from the rhizoma of Cimicifuga dahurica to lower plasma glucose in diabetic rats

Planta Med. 1999 Dec;65(8):712-4. doi: 10.1055/s-1999-14048.

Authors

I M Liu¹, T C Chi, F L Hsu, C F Chen, J T Cheng

Affiliation

¹ Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan City, Taiwan, R.O.C.

PMID: 10630111
DOI: 10.1055/s-1999-14048

Abstract

Isoferulic acid extracted from the rhizome of Cimicifuga dahurica Maxim. (Ranunculaceae) has been determined to have in vivo antihyperglycemic activity. An antihyperglycemic action of isoferulic acid in spontaneously diabetic rats, similar to type I diabetes, is presented.

MeSH terms

Animals
Blood Glucose / analysis*
Cinnamates / isolation & purification
Cinnamates / therapeutic use*
Diabetes Mellitus, Type 1 / blood
Diabetes Mellitus, Type 1 / drug therapy*
Disease Models, Animal
Hypoglycemic Agents / isolation & purification
Hypoglycemic Agents / therapeutic use*
Male
Plants, Medicinal / chemistry*
Rats
Rats, Wistar

Substances

Blood Glucose
Cinnamates
Hypoglycemic Agents
isoferulic acid