Plasma sialyltransferase activity in healthy subjects and atherosclerotic patients

E V Gracheva; N K Golovanova; M V Ezhov; P P Malyshev; V V Kukharchuk; N V Prokazova

Plasma sialyltransferase activity in healthy subjects and atherosclerotic patients

Biochemistry (Mosc). 1999 Nov;64(11):1315-9.

Authors

E V Gracheva¹, N K Golovanova, M V Ezhov, P P Malyshev, V V Kukharchuk, N V Prokazova

Affiliation

¹ Institute of Experimental Cardiology, Cardiology Research Center, Russian Ministry of Health, Moscow, 121552, Russia.

PMID: 10611539

Abstract

Plasma sialyltransferase activity measured by incorporation of cytidine 5;-phospho[14C]acetylneuraminic acid (CMP-NeuAc) into asialofetuin was twofold higher in patients with documented atherosclerosis than in healthy donors. Kinetic studies showed that the enzyme affinity for CMP-NeuAc is the same in donors and patients. Low activity of plasma sialyltransferase in donors may be due to low blood content of this enzyme.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Arteriosclerosis / blood
Arteriosclerosis / enzymology*
Case-Control Studies
Cytidine Monophosphate / metabolism
Humans
Sialyltransferases / blood*

Substances

Sialyltransferases
Cytidine Monophosphate