The identification of a complex A/G/I/J recombinant HIV type 1 virus in various West African countries

AIDS Res Hum Retroviruses. 1999 Dec 10;15(18):1707-12. doi: 10.1089/088922299309757.

Abstract

In this sequence note we describe the full-length genome sequence of an HIV-1 isolate originating from the west African country of Mali. The phylogenetic tree analysis from the near full-length genome shows that the 95ML84 strain forms a separate cluster, supported by 100% of the bootstrap values, with the previously described A/G/J/? mosaic virus BFP90 from Burkina Faso. Additional analysis showed that throughout the genome the lowest diversity was seen between the 95ML84 and the BFP90 viruses, and bootscan analysis showed a similar complex genomic structure. In addition to the initial report describing the BFP90 virus as an A/G/J/? recombinant, our data show that for the BFP90 and 95ML84 strains the unclassified region corresponds to subtype I. The A/G/I/J BFP90 and 95ML84 strains represent the fifth and most complex circulating recombinant form of HIV-1 detected so far, and our data show its presence in various West African countries. Subtype I and J sequences, initially considered rare, seem to have broadened their geographical spread by way of these recombinant forms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Burkina Faso / epidemiology
  • Evolution, Molecular
  • Genetic Variation
  • Genome, Viral*
  • HIV Infections / epidemiology
  • HIV Infections / virology*
  • HIV-1 / classification
  • HIV-1 / genetics
  • HIV-1 / isolation & purification*
  • Humans
  • Mali / epidemiology
  • Molecular Sequence Data
  • Phylogeny
  • Recombination, Genetic

Associated data

  • GENBANK/AJ245481
  • GENBANK/AJ245482
  • GENBANK/AJ245483
  • GENBANK/AJ245484
  • GENBANK/AJ245485
  • GENBANK/AJ245486
  • GENBANK/AJ245487