Evidence that expression of the Vibrio vulnificus hemolysin gene is dependent on cyclic AMP and cyclic AMP receptor protein

Y B Bang; S E Lee; J H Rhee; S H Choi

doi:10.1128/JB.181.24.7639-7642.1999

Evidence that expression of the Vibrio vulnificus hemolysin gene is dependent on cyclic AMP and cyclic AMP receptor protein

J Bacteriol. 1999 Dec;181(24):7639-42. doi: 10.1128/JB.181.24.7639-7642.1999.

Authors

Y B Bang¹, S E Lee, J H Rhee, S H Choi

Affiliation

¹ Department of Food Science and Technology, Institute of Biotechnology, Chonnam National University, Kwang-Ju, 500-757.

Abstract

Glucose repressed hemolysin production in Vibrio vulnificus. Promoter activity of the hemolysin gene, vvh, assessed with a vvh-luxCDABE transcriptional fusion, required cyclic AMP (cAMP) and cAMP receptor protein (CRP) in Escherichia coli. Hemolysin production in V. vulnificus increased after the addition of cAMP and was undetectable in a putative crp mutant, suggesting that vvh is also regulated by cAMP-CRP in V. vulnificus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cyclic AMP / physiology*
Cyclic AMP Receptor Protein / physiology*
Gene Expression Regulation, Bacterial
Glucose / metabolism
Hemolysin Proteins / genetics*
Humans
Promoter Regions, Genetic
Sheep
Vibrio / genetics*
Vibrio / metabolism

Substances

Cyclic AMP Receptor Protein
Hemolysin Proteins
Cyclic AMP
Glucose