Diuretic effects on calcium metabolism

Semin Nephrol. 1999 Nov;19(6):551-6.

Abstract

Diuretics have numerous effects on calcium metabolism. The loop diuretics promote, and the thiazide diuretics inhibit, renal calcium excretion. In this review we detail the basic mechanisms of renal calcium excretion and then explain how diuretics influence this excretion. Finally we review how these agents can be used to alter calcium homeostasis in a clinically efficacious manner.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Transport / drug effects
  • Biological Transport / physiology
  • Calcium / metabolism*
  • Calcium Channels / drug effects*
  • Diuretics / classification
  • Diuretics / pharmacology*
  • Humans
  • Kidney Tubules, Distal / drug effects*
  • Kidney Tubules, Distal / physiology
  • Kidney Tubules, Proximal / drug effects*
  • Kidney Tubules, Proximal / physiology
  • Loop of Henle / drug effects*
  • Loop of Henle / physiology

Substances

  • Calcium Channels
  • Diuretics
  • Calcium