Environmental covariates: effects on the power of sib-pair linkage methods

Genet Epidemiol. 1999:17 Suppl 1:S643-8. doi: 10.1002/gepi.13701707105.

Abstract

The effect of inclusion of environmental risk factors on the power of sib-pair linkage methods was tested for a qualitative trait. It was found that inclusion of an environmental variable did not increase the power of the Haseman-Elston (H-E) sib-pair nonparametric linkage analysis test. However, a significant increase in power was observed for both the H-E and affected-sib-pair tests, even in small samples, when persons unexposed to the environmental risk factor were coded as unknown.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Environment*
  • Genetic Linkage*
  • Genetic Predisposition to Disease
  • Genetic Testing
  • Genome
  • Genotype
  • Humans
  • Models, Genetic*
  • Nuclear Family
  • Quantitative Trait, Heritable