Autoantibodies against oxidized LDL in the first phase of life. Low density lipoproteins

Clin Chem Lab Med. 1999 Sep;37(9):913-7. doi: 10.1515/CCLM.1999.135.

Abstract

The study presents a comparison of data concerning lipid metabolism and lipid oxidation (oxidative stress) in children at the time of their birth and 3 months later, as well as of their mothers at the time of delivery, compared to a control group of non-pregnant women of the same age. The data confirm that labour represents an oxidative stress for both mother and child; it is expressed as a significant increase of malondialdehyde concentration in mothers immediately after delivery in comparison with non-pregnant women (p<0.001). Its concentration in newborns was even higher than in their mothers (p<0.005). Concentration of antibodies against oxidized LDL (oxLDLAb) was comparable in mothers and newborns due to their transplacental transport. During the first three months of life these autoantibodies increased almost two-fold. The importance of this unique observation is discussed with respect to possible early atherogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autoantibodies / analysis*
  • Cholesterol / blood
  • Female
  • Free Radicals
  • Humans
  • Infant, Newborn / blood
  • Infant, Newborn / immunology*
  • Lipoproteins, LDL / immunology*
  • Male
  • Malondialdehyde / blood
  • Oxidative Stress
  • Superoxide Dismutase / blood

Substances

  • Autoantibodies
  • Free Radicals
  • Lipoproteins, LDL
  • oxidized low density lipoprotein
  • Malondialdehyde
  • Cholesterol
  • Superoxide Dismutase