Abstract
Variegation and inherited somatic mosaicism has been observed in transgenic mice carrying yeast artificial chromosomes (YACs) in which a DNAse I hypersensitive site (HS) located -12 kb upstream of the mouse tyrosinase gene had been deleted. At present, we are generating new transgenic animals with minor deletions of the HS.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Animals, Genetically Modified
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Chromosomes, Artificial, Yeast*
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DNA, Recombinant / genetics
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DNA, Recombinant / metabolism
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Deoxyribonuclease I / metabolism
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Genes, Synthetic
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Hair Color / genetics
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Mice
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Mice, Transgenic
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Monophenol Monooxygenase / biosynthesis
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Monophenol Monooxygenase / genetics*
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Mosaicism
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Recombinant Fusion Proteins / biosynthesis
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Recombinant Fusion Proteins / genetics
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Sequence Deletion
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Transgenes*
Substances
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DNA, Recombinant
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Recombinant Fusion Proteins
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Monophenol Monooxygenase
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Deoxyribonuclease I