The authors describe a group of eight patients (four women and four men) with diffuse retinal pigmented epiteliopathy (four times unilateral and four times bilateral) confirmed by fluoroangiography, in one instance with bullous elevation of the retina. The mean age of the patients was 57.3 years, the investigation period was 4 to 23 years, with a mean of 8.6 years. After laser coagulation which was implemented in four patients vision improved in one instance, in the remaining patients vision was stabilized. In the patient with the bullous elevation of the retina vision improved after spontaneous flattening of the ablation. The authors discuss the pathogenesis and clinical features typical for diffuse retinal pigmented epitheliopathy.