Salt water promotes hypertension in Dahl-S rats

Exp Anim. 1999 Oct;48(4):289-92. doi: 10.1538/expanim.48.289.

Abstract

Hypertension was induced in Dahl-salt-sensitive (Dahl-S) rats by administering salt in drinking water. Control rats receiving tap water did not show a significant change in blood pressure or abnormalities in the kidney. Rats receiving 0.5% NaCl solution developed moderate hypertension and renal lesions. Rats receiving 1.0% NaCl solution showed prominent and increasing hypertension and severe renal damage. This method of salt administration should be simpler than administration in the diet as a means of promoting renal hypertension. The lower concentration salt water caused chronic mild hypertension in Dahl-S rats, and may serve as a useful model for progressive hypertension.

MeSH terms

  • Animals
  • Blood Pressure / drug effects
  • Blood Pressure / physiology
  • Heart / drug effects
  • Hypertension, Renal / chemically induced*
  • Hypertension, Renal / pathology
  • Hypertension, Renal / physiopathology
  • Kidney / drug effects*
  • Kidney / physiopathology
  • Male
  • Myocardium / pathology
  • Organ Size / drug effects
  • Rats
  • Rats, Inbred Dahl
  • Sodium Chloride / pharmacology*

Substances

  • Sodium Chloride