In vitro activities of ketolide HMR3647, macrolides, and other antibiotics against Lactobacillus, Leuconostoc, and Pediococcus isolates

Antimicrob Agents Chemother. 1999 Dec;43(12):3039-41. doi: 10.1128/AAC.43.12.3039.

Abstract

Testing of susceptibility to 13 antibiotics was performed with 90 isolates of Lactobacillus, Leuconostoc, and Pediococcus. MICs at which 90% of the isolates tested were inhibited by HMR3647, erythromycin, and ciprofloxacin were 0.015, 0.125 and 32 microg/ml, respectively. The penicillin MIC was > or = 16 microg/ml against 26.2% of the studied Lactobacillus sp. isolates and 50% of Lactobacillus plantarum. HMR3647 showed excellent activity against these genera.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Anti-Infective Agents / pharmacology
  • Ciprofloxacin / pharmacology
  • Erythromycin / pharmacology
  • Ketolides*
  • Lactobacillus / drug effects*
  • Lactobacillus / genetics
  • Leuconostoc / drug effects*
  • Leuconostoc / genetics
  • Macrolides*
  • Microbial Sensitivity Tests
  • Pediococcus / drug effects*
  • Pediococcus / genetics

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Ketolides
  • Macrolides
  • Ciprofloxacin
  • Erythromycin
  • telithromycin