Abstract
The activity-guided fractionation of the extract of the root of Salvia miltiorrhiza B. (Labiatae, Tanshen), led to the isolation of four active components responsible for the anti-allergic activity in vitro. Among them, 15,16-dihydrotanshinone-I and cryptotanshinone demonstrated significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells in a dose-dependent manner; the IC50 values were calculated as 16 and 36 microM, respectively.
MeSH terms
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Animals
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Anti-Allergic Agents / chemistry
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Anti-Allergic Agents / isolation & purification
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Anti-Allergic Agents / pharmacology*
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Cell Degranulation / drug effects*
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Cell Line
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Furans
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Lamiaceae / chemistry*
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Mast Cells / drug effects*
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Mast Cells / enzymology
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Phenanthrenes / chemistry
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Phenanthrenes / isolation & purification
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Phenanthrenes / pharmacology*
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plant Roots / chemistry
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Plant Roots / metabolism
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Quinones
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beta-N-Acetylhexosaminidases / metabolism
Substances
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Anti-Allergic Agents
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Furans
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Phenanthrenes
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Plant Extracts
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Quinones
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dihydrotanshinone I
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cryptotanshinone
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beta-N-Acetylhexosaminidases