Gastrointestinal bleeding in infants and children is a common problem in the practice of general pediatrics. This report outlines the diagnosis and management of gastrointestinal bleeding in children that does not require surgical or invasive intervention. The spectrum of responsible entities are quite diverse and include a variety of immune-mediated diseases, peptic diseases, drug induced disorders, infections, and coagulation disorders. Through understanding the nature of the above-described problems, appropriate diagnostic and management principles can be applied.