Stabilization of microtubules by Combretastatin D derivatives

E A Couladouros; T Li; V I Moutsos; E N Pitsinos; I C Soufli

doi:10.1016/s0960-894x(99)00503-x

Stabilization of microtubules by Combretastatin D derivatives

Bioorg Med Chem Lett. 1999 Oct 18;9(20):2927-8. doi: 10.1016/s0960-894x(99)00503-x.

Authors

E A Couladouros¹, T Li, V I Moutsos, E N Pitsinos, I C Soufli

Affiliation

¹ Chemistry Laboratories, Agricultural University of Athens, Greece. ecoula@mail.ariadne-t.gr

PMID: 10571149
DOI: 10.1016/s0960-894x(99)00503-x

Abstract

The effect of five derivatives of Combretastatin D on tubulin polymerization was investigated. All of them were found to stabilize microtubules to various degrees. The derivatives bearing polar substituents were found to be the most active.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bibenzyls / chemistry
Bibenzyls / pharmacology*
Microtubules / drug effects*
Molecular Structure
Stilbenes*

Substances

Bibenzyls
Stilbenes
combretastatin