Cerebrospinal fluid isoprostane shows oxidative stress in patients with multiple sclerosis

Neurology. 1999 Nov 10;53(8):1876-9. doi: 10.1212/wnl.53.8.1876.

Abstract

The CSF level of the isoprostane 8-epi-prostaglandin (PG)-F2alpha (a reliable marker of oxidative stress in vivo) was three times higher in subjects with definite MS than in a benchmark group of subjects with other neurologic diseases. This increase was not correlated with that of PGE2 levels, measured as an index of cyclooxygenase activity, and was much lower in steroid-treated patients. The levels of 8-epi-PGF2alpha were moderately correlated with the degree of disability.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Dinoprost / analogs & derivatives*
  • Dinoprost / cerebrospinal fluid
  • Dinoprostone / cerebrospinal fluid
  • Disabled Persons
  • F2-Isoprostanes
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis / cerebrospinal fluid
  • Multiple Sclerosis / metabolism*
  • Multiple Sclerosis / physiopathology
  • Osmolar Concentration
  • Oxidative Stress*
  • Prostaglandin-Endoperoxide Synthases / metabolism
  • Reference Values

Substances

  • F2-Isoprostanes
  • 8-epi-prostaglandin F2alpha
  • Dinoprost
  • Prostaglandin-Endoperoxide Synthases
  • Dinoprostone